Gerald Shadel appointed the Madri Professor of Experimental Pathology

Gerald S. Shadel, newly named as the Joseph A. and Lucille K. Madri Professor of Experimental Pathology, focuses his research on the role of mitochondria in disease, aging, and the immune system.

Shadel’s laboratory has made seminal contributions to the current understanding of mitochondrial gene regulation and mtDNA metabolism; pioneered aging studies showing that mitochondrial respiration and ROS signaling are key components of conserved longevity pathways; and developed and analyzed novel animal models of mitochondrial diseases and stress responses.

A graduate of the University of Nevada-Las Vegas, Shadel received his Ph.D. in biochemistry from Texas A&M University. Following postdoctoral training in the Department of Developmental Biology at Stanford University, Shadel began his independent academic career as an assistant professor of biochemistry at Emory University. In 2004 he joined the faculty at the Yale School of Medicine, where he is currently a tenured professor in the Department of Pathology with a secondary appointment in the Department of Genetics. He is also director of the Yale Center for Research on Aging (Y-Age).

Shadel has contributed scores of published research articles, book chapters, reviews, and commentaries. He serves on the editorial boards of Aging, Aging Cell, and Frontiers in Genetics: Aging, among other publications. He has delivered invited lectures at universities and professional organizations throughout the United States as well as in Europe and Asia. Shadel has mentored dozens of undergraduate, graduate and postdoctoral students, many of whom have gone to successful careers in academics and the private sector.

The Yale professor’s honors include the Amgen Outstanding Investigator Award from the American Society for Investigative Pathology, the Glenn Award for Research in Biological Mechanisms of Aging from the Glenn Foundation for Medical Research, and he was keynote speaker at the 2015 FASEB meeting on Mitochondrial Biogenesis and Dynamics in Health, Disease and Aging. Shadel is a member of the American Association for the Advancement of Science, the American Society for Biochemistry and Molecular Biology, the Mitochondrial Research Society, and the American Society for Investigative Pathology.